Prep the Fish: Rinse and pat dry the catfish fillets.
Season: In a small bowl, combine paprika, cayenne, garlic powder, onion powder, thyme, oregano, salt, and pepper. Rub the spice blend evenly over both sides of the fillets.
Cook: Heat butter in a cast-iron skillet over medium-high heat until smoking hot. Carefully place the fillets in the skillet. Cook for 3–4 minutes per side, until the spices form a dark crust and the fish flakes easily with a fork.
Serve: Transfer to plates and serve immediately with lemon wedges, rice, or sautéed vegetables.
