Prepare the Brisket:
Trim excess fat from the brisket if desired. Mix brown sugar, paprika, garlic powder, onion powder, salt, pepper, and cayenne to make a dry rub. Rub the mixture all over the brisket. Cover and let it sit for several hours or overnight in the fridge for maximum flavor.Preheat Smoker or Grill:
Preheat to 225°F (107°C) for low-and-slow cooking.Smoke the Brisket:
Place the brisket on the smoker or grill, fat side up. Smoke slowly for several hours, basting with BBQ sauce every hour to enhance flavor and moisture.Check for Doneness:
Cook until the internal temperature reaches 190°F (88°C) and the meat is tender enough to pull apart easily.Rest and Slice:
Let the brisket rest for 20–30 minutes before slicing against the grain. Serve with additional BBQ sauce.
